Journal of Pathology and Translational Medicine

Review

Interpretation of PD-L1 expression in gastric cancer: summary of a consensus meeting of Korean gastrointestinal pathologists: Soomin Ahn, Yoonjin Kwak, Gui Young Kwon, Kyoung-Mee Kim, Moonsik Kim, Hyunki Kim, Young Soo Park, Hyeon Jeong Oh, Kyoungyul Lee, Sung Hak Lee, Hye Seung Lee; Received February 22, 2024 Accepted March 14, 2024 Published online April 25, 2024; DOI: https://doi.org/10.4132/jptm.2024.03.15 [Epub ahead of print]

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Abstract PDF: Nivolumab plus chemotherapy in the first-line setting has demonstrated clinical efficacy in patients with human epidermal growth factor receptor 2–negative advanced or metastatic gastric cancer, and is currently indicated as a standard treatment. Programmed death-ligand 1 (PD-L1) expression is an important biomarker for predicting response to anti–programmed death 1/PD-L1 agents in several solid tumors, including gastric cancer. In the CheckMate-649 trial, significant clinical improvements were observed in patients with PD-L1 combined positive score (CPS) ≥ 5, determined using the 28-8 pharmDx assay. Accordingly, an accurate interpretation of PD-L1 CPS, especially at a cutoff of 5, is important. The CPS method evaluates both immune and tumor cells and provides a comprehensive assessment of PD-L1 expression in the tumor microenvironment of gastric cancer. However, CPS evaluation has several limitations, one of which is poor interobserver concordance among pathologists. Despite these limitations, clinical indications relying on PD-L1 CPS are increasing. In response, Korean gastrointestinal pathologists held a consensus meeting for the interpretation of PD-L1 CPS in gastric cancer. Eleven pathologists reviewed 20 PD-L1 slides with a CPS cutoff close to 5, stained with the 28-8 pharmDx assay, and determined the consensus scores. The issues observed in discrepant cases were discussed. In this review, we present cases of gastric cancer with consensus PD-L1 CPS. In addition, we briefly touch upon current practices and clinical issues associated with assays used for the assessment of PD-L1 expression in gastric cancer.

Original Articles

Prognostic Impact of Fusobacterium nucleatum Depends on Combined Tumor Location and Microsatellite Instability Status in Stage II/III Colorectal Cancers Treated with Adjuvant Chemotherapy: Hyeon Jeong Oh, Jung Ho Kim, Jeong Mo Bae, Hyun Jung Kim, Nam-Yun Cho, Gyeong Hoon Kang; J Pathol Transl Med. 2019;53(1):40-49. Published online December 26, 2018; DOI: https://doi.org/10.4132/jptm.2018.11.29

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Background
This study aimed to investigate the prognostic impact of intratumoral Fusobacterium nucleatum in colorectal cancer (CRC) treated with adjuvant chemotherapy.
Methods
F. nucleatumDNA was quantitatively measured in a total of 593 CRC tissues retrospectively collectedfrom surgically resected specimens of stage III or high-risk stage II CRC patients who had receivedcurative surgery and subsequent oxaliplatin-based adjuvant chemotherapy (either FOLFOXor CAPOX). Each case was classified into one of the three categories: F. nucleatum–high, –low, or –negative.
Results
No significant differences in survival were observed between the F.nucleatum–high and –low/negative groups in the 593 CRCs (p = .671). Subgroup analyses accordingto tumor location demonstrated that disease-free survival was significantly better in F.nucleatum–high than in –low/negative patients with non-sigmoid colon cancer (including cecal,ascending, transverse, and descending colon cancers; n = 219; log-rank p = .026). In multivariateanalysis, F. nucleatum was determined to be an independent prognostic factor in non-sigmoidcolon cancers (hazard ratio, 0.42; 95% confidence interval, 0.18 to 0.97; p = .043). Furthermore,the favorable prognostic effect of F. nucleatum–high was observed only in a non-microsatellite instability-high (non-MSI-high) subset of non-sigmoid colon cancers (log-rank p = 0.014), but not ina MSI-high subset (log-rank p = 0.844), suggesting that the combined status of tumor locationand MSI may be a critical factor for different prognostic impacts of F. nucleatum in CRCs treatedwith adjuvant chemotherapy.
Conclusions
Intratumoral F. nucleatum load is a potential prognosticfactor in a non-MSI-high/non-sigmoid/non-rectal cancer subset of stage II/III CRCs treatedwith oxaliplatin-based adjuvant chemotherapy.

Citations

Citations to this article as recorded by

Composition of the colon microbiota in the individuals with inflammatory bowel disease and colon cancer
Ceren Acar, Sibel Kucukyildirim Celik, H. Ozgur Ozdemirel, Beril Erdem Tuncdemir, Saadet Alan, Hatice Mergen
Folia Microbiologica.2024; 69(2): 333. CrossRef
Intratumoral microorganisms in tumors of the digestive system
Mengjuan Xuan, Xinyu Gu, Yingru Liu, Li Yang, Yi Li, Di Huang, Juan Li, Chen Xue
Cell Communication and Signaling.2024;[Epub] CrossRef
Prognostic impact of oral microbiome on survival of malignancies: a systematic review and meta-analysis
Shuluan Li, Tianyu Wang, Ya Ren, Zhou Liu, Jidong Gao, Zhi Guo
Systematic Reviews.2024;[Epub] CrossRef
Exploring the Potential of Humoral Immune Response to Commensal Bifidobacterium as a Biomarker for Human Health, including Both Malignant and Non-Malignant Diseases: A Perspective on Detection Strategies and Future Directions
Kyogo Itoh, Satoko Matsueda
Biomedicines.2024; 12(4): 803. CrossRef
Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy
Jinjing Zhang, Penghui Wang, Jiafeng Wang, Xiaojie Wei, Mengchuan Wang
Pharmacological Research.2024; 203: 107185. CrossRef
Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy
Li Yang, Aitian Li, Ying Wang, Yi Zhang
Signal Transduction and Targeted Therapy.2023;[Epub] CrossRef
Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome
William P. Duggan, Manuela Salvucci, Batuhan Kisakol, Andreas U. Lindner, Ian S. Reynolds, Heiko Dussmann, Joanna Fay, Tony O’Grady, Daniel B. Longley, Fiona Ginty, Elizabeth Mc Donough, Daniel J. Slade, John P. Burke, Jochen H. M. Prehn
Journal of Molecular Medicine.2023; 101(7): 829. CrossRef
Fusobacterium nucleatum Load Correlates with KRAS Mutation and Sessile Serrated Pathogenesis in Colorectal Adenocarcinoma
Koki Takeda, Minoru Koi, Yoshiki Okita, Sija Sajibu, Temitope O. Keku, John M. Carethers
Cancer Research Communications.2023; 3(9): 1940. CrossRef
La asociación entre Fusobacterium nucleatum y el cáncer colorrectal: una revisión sistemática y metaanálisis
Paola Villar-Ortega, Manuela Expósito-Ruiz, Miguel Gutiérrez-Soto, Miguel Ruiz-Cabello Jiménez, José María Navarro-Marí, José Gutiérrez-Fernández
Enfermedades Infecciosas y Microbiología Clínica.2022; 40(5): 224. CrossRef
The association between Fusobacterium nucleatum and cancer colorectal: A systematic review and meta-analysis
Paola Villar-Ortega, Manuela Expósito-Ruiz, Miguel Gutiérrez-Soto, Miguel Ruiz-Cabello Jiménez, José María Navarro-Marí, José Gutiérrez-Fernández
Enfermedades infecciosas y microbiologia clinica (English ed.).2022; 40(5): 224. CrossRef
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Chao Huang, Ying Sun, Sheng-rong Liao, Zhao-xin Chen, Han-feng Lin, Wei-zeng Shen
Frontiers in Microbiology.2022;[Epub] CrossRef
Prognostic and clinicopathological significance of Fusobacterium nucleatum in colorectal cancer: a systemic review and meta-analysis
Younghoon Kim, Nam Yun Cho, Gyeong Hoon Kang
Journal of Pathology and Translational Medicine.2022; 56(3): 144. CrossRef
Iron accelerates Fusobacterium nucleatum–induced CCL8 expression in macrophages and is associated with colorectal cancer progression
Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Taka
JCI Insight.2022;[Epub] CrossRef
Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
Yi Wang, Yuting Wen, Jiayin Wang, Xin Lai, Ying Xu, Xuanping Zhang, Xiaoyan Zhu, Chenglin Ruan, Yao Huang
Frontiers in Microbiology.2022;[Epub] CrossRef
Clinical Significance of Fusobacterium nucleatum and Microsatellite Instability in Evaluating Colorectal Cancer Prognosis
Yanxuan Xie, Xiaoyang Jiao, Mi Zeng, Zhiqiang Fan, Xin Li, Yumeng Yuan, Qiaoxin Zhang, Yong Xia
Cancer Management and Research.2022; Volume 14: 3021. CrossRef
Influence of the Microbiome Metagenomics and Epigenomics on Gastric Cancer
Precious Mathebela, Botle Precious Damane, Thanyani Victor Mulaudzi, Zilungile Lynette Mkhize-Khwitshana, Guy Roger Gaudji, Zodwa Dlamini
International Journal of Molecular Sciences.2022; 23(22): 13750. CrossRef
Circulating IgA Antibodies Against Fusobacterium nucleatum Amyloid Adhesin FadA are a Potential Biomarker for Colorectal Neoplasia
Jung Eun Baik, Li Li, Manish A. Shah, Daniel E. Freedberg, Zhezhen Jin, Timothy C. Wang, Yiping W. Han
Cancer Research Communications.2022; 2(11): 1497. CrossRef
Differential immune microenvironmental features of microsatellite-unstable colorectal cancers according to Fusobacterium nucleatum status
Ji Ae Lee, Seung-Yeon Yoo, Hyeon Jeong Oh, Seorin Jeong, Nam-Yun Cho, Gyeong Hoon Kang, Jung Ho Kim
Cancer Immunology, Immunotherapy.2021; 70(1): 47. CrossRef
Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study
Yannick Eisele, Patrick M. Mallea, Biljana Gigic, W. Zac Stephens, Christy A. Warby, Kate Buhrke, Tengda Lin, Juergen Boehm, Petra Schrotz-King, Sheetal Hardikar, Lyen C. Huang, T. Bartley Pickron, Courtney L. Scaife, Richard Viskochil, Torsten Koelsch, A
Clinical Colorectal Cancer.2021; 20(3): e165. CrossRef
Role of gut microbiota in epigenetic regulation of colorectal Cancer
Yinghui Zhao, Chuanxin Wang, Ajay Goel
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1875(1): 188490. CrossRef
Fusobacterium nucleatum: caution with interpreting historical patient sample cohort
Kate L. F. Johnstone, Sinead Toomey, Stephen Madden, Brian D. P. O’Neill, Bryan T Hennessy
Journal of Pathology and Translational Medicine.2021; 55(6): 415. CrossRef
Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients
Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Te-Sheng Chang, Kuo-Liang Wei, Wei-Ming Chen, Yi-Fang Deng, Chung-Kuang Lu, Yu-Hsuan Lai, Cheng-Shyong Wu, Chin Li
World Journal of Gastroenterology.2021; 27(42): 7311. CrossRef
Analysis of changes in microbiome compositions related to the prognosis of colorectal cancer patients based on tissue-derived 16S rRNA sequences
Sukjung Choi, Jongsuk Chung, Mi-La Cho, Donghyun Park, Sun Shim Choi
Journal of Translational Medicine.2021;[Epub] CrossRef
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World Journal of Meta-Analysis.2021; 9(6): 505. CrossRef
Gut Microbiota Profiles in Early- and Late-Onset Colorectal Cancer: A Potential Diagnostic Biomarker in the Future
Murdani Abdullah, Ninik Sukartini, Saskia Aziza Nursyirwan, Rabbinu Rangga Pribadi, Hasan Maulahela, Amanda Pitarini Utari, Virly Nanda Muzellina, Agustinus Wiraatmadja, Kaka Renaldi
Digestion.2021; 102(6): 823. CrossRef
The effect of periodontal bacteria infection on incidence and prognosis of cancer
Li Xiao, Qianyu Zhang, Yanshuang Peng, Daqing Wang, Ying Liu
Medicine.2020; 99(15): e19698. CrossRef
The impact of the gut microbiota on prognosis after surgery for colorectal cancer – a systematic review and meta‐analysis
Emilie Palmgren Colov, Thea Helene Degett, Hans Raskov, Ismail Gögenur
APMIS.2020; 128(2): 162. CrossRef
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Expert Review of Clinical Pharmacology.2020; 13(4): 403. CrossRef
Predictive values of colon microbiota in the treatment response to colorectal cancer
Jorge Galan-Ros, Verónica Ramos-Arenas, Pablo Conesa-Zamora
Pharmacogenomics.2020; 21(14): 1045. CrossRef
The gut microbiome and potential implications for early-onset colorectal cancer
Reetu Mukherji, Benjamin A Weinberg
Colorectal Cancer.2020;[Epub] CrossRef
Fusobacterium nucleatum in the Colorectum and Its Association with Cancer Risk and Survival: A Systematic Review and Meta-analysis
Christian Gethings-Behncke, Helen G. Coleman, Haydee W.T. Jordao, Daniel B. Longley, Nyree Crawford, Liam J. Murray, Andrew T. Kunzmann
Cancer Epidemiology, Biomarkers & Prevention.2020; 29(3): 539. CrossRef
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Ji Ae Lee, Hye Eun Park, Seung-Yeon Yoo, Seorin Jeong, Nam-Yun Cho, Gyeong Hoon Kang, Jung Ho Kim
Journal of Pathology and Translational Medicine.2019; 53(4): 225. CrossRef
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients
Andrew T. Kunzmann, Marcela Alcântara Proença, Haydee WT Jordao, Katerina Jiraskova, Michaela Schneiderova, Miroslav Levy, Václav Liska, Tomas Buchler, Ludmila Vodickova, Veronika Vymetalkova, Ana Elizabete Silva, Pavel Vodicka, David J. Hughes
European Journal of Clinical Microbiology & Infectious Diseases.2019; 38(10): 1891. CrossRef
Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer
Sally Temraz, Farah Nassar, Rihab Nasr, Maya Charafeddine, Deborah Mukherji, Ali Shamseddine
International Journal of Molecular Sciences.2019; 20(17): 4155. CrossRef
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Journal of Oncology.2019; 2019: 1. CrossRef
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Chronic Diseases and Translational Medicine.2019; 5(3): 178. CrossRef

Overexpression of POSTN in Tumor Stroma Is a Poor Prognostic Indicator of Colorectal Cancer: Hyeon Jeong Oh, Jeong Mo Bae, Xian-Yu Wen, Nam-Yun Cho, Jung Ho Kim, Gyeong Hoon Kang; J Pathol Transl Med. 2017;51(3):306-313. Published online April 12, 2017; DOI: https://doi.org/10.4132/jptm.2017.01.19

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Abstract PDF

Background
Tumor microenvironment has recently drawn attention in that it is related with tumor prognosis. Cancer-associated fibroblast also plays a critical role in cancer invasiveness and progression in colorectal cancers. Periostin (POSTN), originally identified to be expressed in osteoblasts and osteoblast-derived cells, is expressed in cancer-associated fibroblasts in several tissue types of cancer. Recent studies suggest an association between stromal overexpression of POSTN and poor prognosis of cancer patients.
Methods
We analyzed colorectal cancer cases for their expression status of POSTN in tumor stroma using immunohistochemistry and correlated the expression status with clinicopathological and molecular features.
Results
High level of POSTN expression in tumor stroma was closely associated with tumor location in proximal colon, infiltrative growth pattern, undifferentiated histology, tumor budding, luminal necrosis, and higher TNM stage. High expression status of POSTN in tumor stroma was found to be an independent prognostic parameter implicating poor 5-year cancer-specific survival and 5-year progression-free survival.
Conclusions
Our findings suggest that POSTN overexpression in tumor stroma of colorectal cancers could be a possible candidate marker for predicting poor prognosis in patients with colorectal cancers.

Citations

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Marina Blázquez‐García, Jennifer Quinchia, Víctor Ruiz‐Valdepeñas Montiel, Rebeca M. Torrente‐Rodríguez, Verónica Serafín, María Garranzo‐Asensio, Ana García‐Romero, Jahir Orozco, Rodrigo Barderas, José M. Pingarrón, Susana Campuzano
ChemElectroChem.2024;[Epub] CrossRef
Simultaneous Expression of CD70 and POSTN in Cancer-Associated Fibroblasts Predicts Worse Survival of Colorectal Cancer Patients
Masayuki Komura, Chengbo Wang, Sunao Ito, Shunsuke Kato, Akane Ueki, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Shuji Takiguchi, Satoru Takahashi, Shingo Inaguma
International Journal of Molecular Sciences.2024; 25(5): 2537. CrossRef
SPOCK1 and POSTN are valuable prognostic biomarkers and correlate with tumor immune infiltrates in colorectal cancer
Caiqin Gan, Mengting Li, Yuanyuan Lu, Ganjing Peng, Wenjie Li, Haizhou Wang, Yanan Peng, Qian Hu, Wanhui Wei, Fan Wang, Lan Liu, Qiu Zhao
BMC Gastroenterology.2023;[Epub] CrossRef
Stromal POSTN Enhances Motility of Both Cancer and Stromal Cells and Predicts Poor Survival in Colorectal Cancer
Akane Ueki, Masayuki Komura, Akira Koshino, Chengbo Wang, Kazuhiro Nagao, Mai Homochi, Yuki Tsukada, Masahide Ebi, Naotaka Ogasawara, Toyonori Tsuzuki, Kenji Kasai, Kunio Kasugai, Satoru Takahashi, Shingo Inaguma
Cancers.2023; 15(3): 606. CrossRef
POSTN Secretion by Extracellular Matrix Cancer-Associated Fibroblasts (eCAFs) Correlates with Poor ICB Response via Macrophage Chemotaxis Activation of Akt Signaling Pathway in Gastric Cancer
Tingting You, Hui Tang, Wenjing Wu, Jingxi Gao, Xuechun Li, Ningning Li, Xiuxiu Xu, Jiazhang Xing, Hui Ge, Yi Xiao, Junchao Guo, Bin Wu, Xiaoyi Li, Liangrui Zhou, Lin Zhao, Chunmei Bai, Qin Han, Zhao Sun, Robert Chunhua Zhao
Aging and disease.2023; 14(6): 2177. CrossRef
A Pan-cancer Analysis Reveals the Tissue Specificity and Prognostic Impact of Angiogenesis-associated Genes in Human Cancers
Zhenshen Bao, Minzhen Liao, Wanqi Dong, Yanhao Huo, Xianbin Li, Peng Xu, Wenbin Liu
Current Bioinformatics.2023; 18(8): 670. CrossRef
Cancer‐associated stroma reveals prognostic biomarkers and novel insights into the tumour microenvironment of colorectal cancer and colorectal liver metastases
Kai M. Brown, Aiqun Xue, Ross C. Smith, Jaswinder S. Samra, Anthony J. Gill, Thomas J. Hugh
Cancer Medicine.2022; 11(2): 492. CrossRef
Periostin in Angiogenesis and Inflammation in CRC—A Preliminary Observational Study
Agnieszka Kula, Miriam Dawidowicz, Sylwia Mielcarska, Paweł Kiczmer, Magdalena Chrabańska, Magdalena Rynkiewicz, Elżbieta Świętochowska, Dariusz Waniczek
Medicina.2022; 58(1): 96. CrossRef
Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway
Chaojian Xu, Ziyue Wang, Long Zhang, Yi Feng, Jia Lv, Zhuangzhuang Wu, Rong Yang, Taiyong Wu, Jian Li, Ruhao Zhou, Zhi Tian, Junjun Bai, Huadong Zhang, Yanping Lan, Zhi Lv
Cancer Cell International.2022;[Epub] CrossRef
Periostin in lymph node pre-metastatic niches governs lymphatic endothelial cell functions and metastatic colonization
Lionel Gillot, Alizée Lebeau, Louis Baudin, Charles Pottier, Thomas Louis, Tania Durré, Rémi Longuespée, Gabriel Mazzucchelli, Christophe Nizet, Silvia Blacher, Frédéric Kridelka, Agnès Noël
Cellular and Molecular Life Sciences.2022;[Epub] CrossRef
Prognostic impact of stromal periostin expression in upper urinary tract urothelial carcinoma
Kosuke Miyai, Kazuki Kawamura, Keiichi Ito, Susumu Matsukuma, Hitoshi Tsuda
BMC Cancer.2022;[Epub] CrossRef
Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma
Cindy Neuzillet, Rémy Nicolle, Jérôme Raffenne, Annemilaï Tijeras‐Raballand, Alexia Brunel, Lucile Astorgues‐Xerri, Sophie Vacher, Floriane Arbateraz, Marjorie Fanjul, Marc Hilmi, Rémi Samain, Christophe Klein, Aurélie Perraud, Vinciane Rebours, Muriel Ma
The Journal of Pathology.2022; 258(4): 408. CrossRef
Periostin: biology and function in cancer
Shima Dorafshan, Mahdieh Razmi, Sadegh Safaei, Erica Gentilin, Zahra Madjd, Roya Ghods
Cancer Cell International.2022;[Epub] CrossRef
Periostin as a key molecule defining desmoplastic environment in colorectal cancer
Takahiro Sueyama, Yoshiki Kajiwara, Satsuki Mochizuki, Hideyuki Shimazaki, Eiji Shinto, Kazuo Hase, Hideki Ueno
Virchows Archiv.2021; 478(5): 865. CrossRef
Expression Patterns of Microenvironmental Factors and Tenascin-C at the Invasive Front of Stage II and III Colorectal Cancer: Novel Tumor Prognostic Markers
Mai Hashimoto, Noriyuki Uesugi, Mitsumasa Osakabe, Naoki Yanagawa, Koki Otsuka, Yoshiki Kajiwara, Hideki Ueno, Akira Sasaki, Tamotsu Sugai
Frontiers in Oncology.2021;[Epub] CrossRef
Deregulation of extracellular matrix modeling with molecular prognostic markers revealed by transcriptome sequencing and validations in Oral Tongue squamous cell carcinoma
Soundara Viveka Thangaraj, Vidyarani Shyamsundar, Arvind Krishnamurthy, Vijayalakshmi Ramshankar
Scientific Reports.2021;[Epub] CrossRef
Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model
Xiaopeng Shen, Zhongxian Liu, Chunguang Wang, Feng Xu, Jingyi Zhang, Meng Li, Yang Lei, Ao Wang, Chao Bi, Guoping Zhu
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Radiographical assessment of tumour stroma and treatment outcomes using deep learning: a retrospective, multicohort study
Yuming Jiang, Xiaokun Liang, Zhen Han, Wei Wang, Sujuan Xi, Tuanjie Li, Chuanli Chen, Qingyu Yuan, Na Li, Jiang Yu, Yaoqin Xie, Yikai Xu, Zhiwei Zhou, George A Poultsides, Guoxin Li, Ruijiang Li
The Lancet Digital Health.2021; 3(6): e371. CrossRef
Periostin expression and its supposed roles in benign and malignant thyroid nodules: an immunohistochemical study of 105 cases
Kimihide Kusafuka, Masaru Yamashita, Tomohiro Iwasaki, Chinatsu Tsuchiya, Aki Kubota, Kazuki Hirata, Akinori Murakami, Aya Muramatsu, Kazumori Arai, Makoto Suzuki
Diagnostic Pathology.2021;[Epub] CrossRef
Cancer-associated fibroblasts in colorectal cancer
S. Kamali Zonouzi, P. S. Pezeshki, S. Razi, N. Rezaei
Clinical and Translational Oncology.2021; 24(5): 757. CrossRef
Prognostic value of periostin in multiple solid cancers: A systematic review with meta‐analysis
Tao Yang, Zhengdong Deng, Zhongya Pan, Yawei Qian, Wei Yao, Jianming Wang
Journal of Cellular Physiology.2020; 235(3): 2800. CrossRef
Serum periostin is associated with cancer mortality but not cancer risk in older home-dwelling men: A 8-year prospective analysis of the STRAMBO study
Jean-Charles Rousseau, Cindy Bertholon, Roland Chapurlat, Pawel Szulc
Bone.2020; 132: 115184. CrossRef
Systematic prediction of key genes for ovarian cancer by co‐expression network analysis
Mingyuan Wang, Jinjin Wang, Jinglan Liu, Lili Zhu, Heng Ma, Jiang Zou, Wei Wu, Kangkai Wang
Journal of Cellular and Molecular Medicine.2020; 24(11): 6298. CrossRef
Upregulation of adipocyte enhancer‐binding protein 1 in endothelial cells promotes tumor angiogenesis in colorectal cancer
Akira Yorozu, Eiichiro Yamamoto, Takeshi Niinuma, Akihiro Tsuyada, Reo Maruyama, Hiroshi Kitajima, Yuto Numata, Masahiro Kai, Gota Sudo, Toshiyuki Kubo, Toshihiko Nishidate, Kenji Okita, Ichiro Takemasa, Hiroshi Nakase, Tamotsu Sugai, Kenichi Takano, Hiro
Cancer Science.2020; 111(5): 1631. CrossRef
Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury
Lei Yao, Jie Song, Xiao wen Meng, Jian yun Ge, Bo xiang Du, Jun Yu, Fu hai Ji
Molecular and Cellular Probes.2020; 53: 101596. CrossRef
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Maria Fusaro, Laura Cosmai, Pieter Evenepoel, Thomas L. Nickolas, Angela M. Cheung, Andrea Aghi, Giovanni Tripepi, Mario Plebani, Giorgio Iervasi, Roberto Vettor, Martina Zaninotto, Maura Ravera, Marina Foramitti, Sandro Giannini, Stefania Sella, Maurizio
Nutrients.2020; 12(9): 2717. CrossRef
Periostin regulates autophagy through integrin α5β1 or α6β4 and an AKT‐dependent pathway in colorectal cancer cell migration
Suyanee Thongchot, Ekapot Singsuksawat, Nuttavut Sumransub, Ananya Pongpaibul, Attaporn Trakarnsanga, Peti Thuwajit, Chanitra Thuwajit
Journal of Cellular and Molecular Medicine.2020; 24(21): 12421. CrossRef
Genomic, transcriptomic, and viral integration profiles associated with recurrent/metastatic progression in high‐risk human papillomavirus cervical carcinomas
Jing Jing Liu, Jung Yoon Ho, Jung Eum Lee, Soo Young Hur, Jinseon Yoo, Kyu Ryung Kim, Daeun Ryu, Tae Min Kim, Youn Jin Choi
Cancer Medicine.2020; 9(21): 8243. CrossRef
Periostin Secreted by Carcinoma-Associated Fibroblasts Promotes Ovarian Cancer Cell Platinum Resistance Through the PI3K/Akt Signaling Pathway
Lei Chu, Fangce Wang, Wenjun Zhang, Huai-fang Li, Jun Xu, Xiao-wen Tong
Technology in Cancer Research & Treatment.2020; 19: 153303382097753. CrossRef
Overexpression of periostin is positively associated with gastric cancer metastasis through promoting tumor metastasis and invasion
Hai Zhong, Xiang Li, Junhua Zhang, Xu Wu
Journal of Cellular Biochemistry.2019; 120(6): 9927. CrossRef
Genes associated with bowel metastases in ovarian cancer
Andrea Mariani, Chen Wang, Ann L. Oberg, Shaun M. Riska, Michelle Torres, Joseph Kumka, Francesco Multinu, Gunisha Sagar, Debarshi Roy, Deok–Beom Jung, Qing Zhang, Tommaso Grassi, Daniel W. Visscher, Vatsal P. Patel, Ling Jin, Julie K. Staub, William A. C
Gynecologic Oncology.2019; 154(3): 495. CrossRef
Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and Progression
Laura González-González, Javier Alonso
Frontiers in Oncology.2018;[Epub] CrossRef
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Yuanyuan Kang, Jie Liu, Ying Zhang, Yan Sun, Junting Wang, Biying Huang, Ming Zhong
Pathology - Research and Practice.2018; 214(12): 1959. CrossRef
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Jennifer M. Brown, Akiro Mantoku, Afsie Sabokbar, Udo Oppermann, A. Bass Hassan, Akiro Kudo, Nick Athanasou
Clinical Sarcoma Research.2018;[Epub] CrossRef
Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients
Gaurav Chatterjee, Trupti Pai, Thomas Hardiman, Kelly Avery-Kiejda, Rodney J. Scott, Jo Spencer, Sarah E. Pinder, Anita Grigoriadis
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Background
Although there are controversies regarding the benefit of fluoropyrimidine-based adjuvant chemotherapy in patients with microsatellite instability–high (MSI-H) colorectal cancer (CRC), the pathologic features affecting postchemotherapeutic prognosis in these patients have not been fully identified yet. Methods: A total of 26 histopathologic and immunohistochemical factors were comprehensively evaluated in 125 stage II or III MSI-H CRC patients who underwent curative resection followed by fluoropyrimidine-based adjuvant chemotherapy. We statistically analyzed the associations of these factors with disease-free survival (DFS). Results: Using a Kaplan- Meier analysis with log-rank test, we determined that ulceroinfiltrative gross type (p=.003), pT4 (p<.001), pN2 (p=.002), perineural invasion (p=.001), absence of peritumoral lymphoid reaction (p=.041), signet ring cell component (p=.006), and cribriform comedo component (p=.004) were significantly associated with worse DFS in patients receiving oxaliplatin-based adjuvant chemotherapy (n=45). By contrast, pT4 (p<.001) and tumor budding-positivity (p=.032) were significant predictors of poor survival in patients receiving non-oxaliplatin–based adjuvant chemotherapy (n=80). In Cox proportional hazards regression model-based univariate and multivariate analyses, pT category (pT1-3 vs pT4) was the only significant prognostic factor in patients receiving non-oxaliplatin–based adjuvant chemotherapy, whereas pT category, signet ring cell histology and cribriform comedo histology remained independent prognostic factors in patients receiving oxaliplatin-based adjuvant chemotherapy. Conclusions: pT4 status is the most significant pathologic determinant of poor outcome after fluoropyrimidine-based adjuvant chemotherapy in patients with stage II/III MSI-H CRC.

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